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IVF, Egg Donation, and Women’s Health


Quick Summary

To date, more than one million babies have been born worldwide as a result of IVF and in 2003 U.S fertility clinics reported 112,872 IVF cycles. Although there has been considerable medical literature exploring the possible health effects of in vitro fertilization to babies born from this technology, the potential health risks to the women who undergo this process have been less extensively studied.

 

IVF, Egg Donation, and Women’s Health
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Future Research

More research in the areas of ovarian stimulation and health outcomes must be completed before definitive conclusions can be drawn about the risks for women. Existing studies have been limited in a variety of ways, yet there has been some evidence that the drugs used in ovarian stimulation and oocyte retrieval may be associated with increased risk of cancer. Priorities for future research ought to include:

• Reducing the risk of OHSS without impaired pregnancy rates and developing the means to identify women who are at a increased risk of OHSS before initiating treatment.

• Long-term evaluation of larger populations of women who have undergone infertility treatment, with more accurate information about the patients’ specific infertility treatments (e.g., dosages, durations, drug name).

• Studies examining the longterm health outcomes of women undergoing ovarian stimulation and oocyte retrieval for oocyte donation as compared to the outcomes of women undergoing stimulation and retrieval for IVF, to better understand whether other factors, such as a woman’s underlying infertility, play a role in the long-term risks of cancer or other diseases.

Prepared by Ruth Farrell, Susannah Baruch and Kathy Hudson with graphics by Sheryl Wood

Date added:
Jul 14, 2006
Project:
Genetics and Public Policy Center
References:
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References:

Almeida O, Waterreus A, Spry N, et al. One year follow-up study of the association between chemical castration, sex hormones, beta-amyloid, memory and depression in men. Psychoneuroendocrinology. 2004;29:1071-81.

Althuis M, Moghissi K, Westhoff C, et al. Uterine cancer after the use of clomiphene citrate to induce ovulation. American Journal of Epidemiology. 2005;161:607-15.(a)

Althuis M, Scoccia B, Lamb E et al. Melanoma, thyroid, cervical and colon cancer risk after use of fertility drugs. American Journal of Obstetrics and Gynecology. 2005;193:668-74.(b)

Ayhan A, Salman M, elik H, et al. Association between fertility drugs and gynecologic cancers, breast cancer, and childhood cancer. Acta obstetricia et gynecologica Scandinavica. 2004;83:1104-11.

Baron J, Weiderpass E, Newcomb P, et al. Metabolic disorders and breast cancer risk. Cancer Causes Contol. 2001;12:875-80.

Brinton L, Moghissi K, Scoccia B, Westhoff C, Lamb E. Ovulation induction and cancer risk. Fertility and Sterility. 2005;83:261-74.

Brinton L, Lamb E, Moghissi K et al. Ovarian cancer risk associated with varying causes of infertility. Fertility and Sterility. 2004;82:405-14.

Burkman RT, Tang MC, Malone KE, et al. Infertilty drugs and the risk of breast cancer: findings from the National Institute of Child Health and Human Development Women’s Contraceptive and Reproductive Experiences Study. Fertility and Sterility. 2003;79:844-51.

Daelmans C, Smits G, de Maertelaer V et al. Prediction of severity of symptoms in iatrogenic ovarian hyperstimulation syndrome by follicle-stimulating hormone receptor Ser680Asn polymorphism. Journal of Clinical Metabolism. 2004;90:6310-5.

Dahlgren E, Friberg L, Johanson S, et al. Endometrial carcinoma; ovarian dysfunction-a risk factor in young women. European Journal of Obstetrics and Gynecology, and Reproductive Biology 1991;41:143-50.

deBoer E, Tonkwlaar I, Burger C, et al. Are cause of subfertility and in vitro fertilization treatment risk factors for an earlier start of menopause? Menopause: The Journal of the North American Menopause Society. 2005;12:578-88.

Escobedo L, Lee N, Peterson H, et al. Infertility associated endometrial cancer risk may be limited to specific subgroups of infertile women. Obstetrics and Gynecology. 1991;77:124-8.

Greb R, Behre H, Simoni M. Pharmacogenetics in ovarian stimulation. Reproductive Biomedicine Online. 2005;11:589-600.

Gordis L. Epidemiology5th edition. Philadephia: Saunders, 2004.

Jordan C, Belar C, Williams R. Anonymous oocyte donation: a follow-up analysis of donors’ experiences. Journal of Psychomotor Obstetrics and Gynecology. 2004;25:145-151.

Klip H, van Leeuwen F, Schats R, et al. Risk of benign gynaecological diseases and hormonal disorders according to responsiveness to ovarian stimulation in IVF: a follow-up study of 8714 women. Human Reproduction. 2003;18:1951-58.

Lazar K. Wonder drug for men alleged to cause harm in women. Boston Herald. Part 1. August 22, 1999, Part 2 August 23, 1999, and Part 3 August 24, 1999.

Mahdavi A, Pejovic T, and Nezhat F. Induction of ovulation and ovarian cancer: a critical review of the literature. Fertility and Sterility. 2006;85:819-26.

Modan B, Ron E, Lerner-Geva, et al. Cancer incidence in a cohort of infertile women. American Journal of Epidemiology. 1998;361:1810-12.

Modesitt S, Tortolero-Luna G, Robinson J, et al. Ovarian and extraovarian enometriosis-related cancer. Obstetrics and Gynecology. 2002;100:788-95.

Morris, RS, Paulson RJ, Sauer MV, Lobo RA. Predictive value of serum oestradiol concentrations and oocyte number in severe ovarian hyperstimulation syndrome. Human Reproduction. 1995. 10:811-14.

Navot D, “Severe Ovarian Hyperstimulation Syndrome”, in Textbook of Assisted Reproductive Techniques: Laboratory and Clinical Perspectives eds. Gardner D, Weissman A, Howles C, Shoham Z. Martin Dunitz, Ltd.: London, 2001.

Ness R. Endometriosis and ovarian cancer: Thoughts on shared pathophysiology. American J. of Obstetrics and Gynecology. 2003;189:280-94.

Norsigian J. Hearing on human cloning and embryonic stem cell research after Seoul: Examining exploitation, fraud, and ethical problems in the research. Presented to the Subcommittee on Criminal Justice, Drug Policy, and Human Resources, March 7, 2006.

Orvieto R. Can we eliminate severe ovarian hyperstimulation syndrome? Human Reproduction. 2004;20:320-22.

Pierpoint T, McKeigue P, Issacs A, et al. Mortality of women with polycycstic ovary syndrome at longterm follow-up. Journal of Clinical Epidemiology. 1998;51:581-6.

Rossing M, Daling J, Weiss N et al. Ovarian tumors in a cohort of infertile women. New England Journal of Medicine. 1994;331:771-6.

Salhab M, Sarakbi A, Mokbel K. In vitro fertilization and breast cancer risk: a review. International Journal of Women’s Medicine. 2005;50:259-66.

Sauer M, Paulson R, Lobo R. Rare occurrence of ovarian hyperstimulation syndrome in oocyte donors. International Journal of Obstetrics and Gynecology. 1996;52:259-62.

Sauer M. Egg donor solicitation: Problems exist, but do abuses? American Journal of Obstetrics and Gynecology. 2001;1:1-2.

Stern R, Dash R, Bentley R. Malignancy in endometriosis: frequency and comparison of ovarian and extraovarian types. International Journal of Gynecologic Pathology. 1997;176:572-79.

Tanka T, Niimi H, Matsou N, et al. Results of long-term follow-up after treatment of central precocious puberty with leuprorelin acetate: Evaluation of effectiveness of treatment and recovery of gonadal function. The TAP-144-SR Japanese study group on central precocious puberty. Journal of Clinical Endocrinology and Metabolism. 2005;90:1371-76.

Venn A, Watson L, Bruinsma F, et al. Risk of cancer after the use of fertility drugs with in-vitro fertilization. The Lancet. 1999;354:1586-90.

Whittemore AS. The risk of ovarian cancer after treatment for infertility. New England Journal of Medicine. 1994;331:805-06.

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