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Antibiotics and Innovation Project

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Antibiotics and Innovation Project

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Issue Brief

Antibiotic Innovation: The Threat and the Pipeline

Mar 30, 2012

The Superbug Threat explores the emergence of antibiotic-resistant bacteria and its impact on human health, as well as the shrinking pipeline of new antibiotics. More

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Summary	Type
Drug Development for Limited Populations: A New Proposed Pathway Issue Brief Jun 26, 2013 The lack of new antibiotics and the rise in drug resistance have rendered some serious and life-threatening infections untreatable, and the health care community is searching for ways to bring innovative new drugs to patients whose treatment options are limited or nonexistent. More info	Issue Brief
The Battle on the Home Front: The Jonathan Gadsden Story Issue Brief Aug 16, 2012 Since Operations Iraqi Freedom and Enduring Freedom began, many American servicemen and women have been infected with antibiotic-resistant bacteria. While our men and women in uniform increasingly survive severe wounds sustained in combat, their injuries leave them susceptible to life-threatening, hard-to-treat infections. Marine Lance Corporal Jonathan Gadsden’s story reflects the growing need for new antibiotics that can treat these dangerous diseases, against which most drugs are useless. More info	Issue Brief
Unmet Medical Need in Infectious Diseases Issue Brief May 31, 2012 Introduced more than 75 years ago, antibiotics have profoundly transformed health care. Thanks to these drugs and to advances in vaccines and infection control, many formerly devastating bacterial illnesses can be cured or contained. More info	Issue Brief
Reviving the Pipeline of Life-Saving Antibiotics Issue Brief Apr 12, 2012 Antibiotic-resistant infections are a growing public health threat. At the same time, antibiotic innovation is waning. Pew, the IIDSA and PhRMA hosted a one-day conference, Reviving the Pipeline of Life-Saving Antibiotics: Exploring Solutions to Spur Innovation on September 22, 2011, exploring ways to overcome the challenges that hinder the development of new antibiotics. More info	Issue Brief
MRSA: A Deadly Pathogen with Fewer and Fewer Treatment Options Issue Brief Apr 3, 2012 Staphylococcus aureus, or staph, is a common bacterium that exists in our environment and our bodies. Most of the time it does no harm. Sometimes, however, it can cause infection and require treatment. MRSA refers to strains of S. aureus that are resistant to the antibiotic methicillin and a host of other drugs used to treat infection. More info	Issue Brief
Antibiotic Innovation: The Threat and the Pipeline Issue Brief Mar 30, 2012 The Superbug Threat explores the emergence of antibiotic resistant bacteria and its impact on human health, as well as the shrinking pipeline of new antibiotics. More info	Issue Brief
Testimony before the House Committee on Energy and Commerce, Subcommittee on Health Issue Brief Mar 8, 2012 Allan Coukell, Director of Medical Programs, and Sharon Ladin, Director of the Antibiotics and Innovation Project, testify before the House Committee on Energy and Commerce, Subcommittee on Health on stimulating the development of new antibiotics urgently needed to fight serious and life-threatening bacterial infections. More info	Issue Brief
MRSA on the Appalachian Trail: The Story of Steve Weisel Issue Brief Mar 1, 2012 Hiking the Appalachian Trail, Steve Weisel thought little of the blisters on his feet until he discovered they were infected with life-threatening methicillin-resistant Staphylococcus aureus (MRSA) -- an increasingly common "superbug" that does not respond to first-line antibiotics. Mr. Weisel's story demonstrates the urgent need for new and innovative therapies to treat this growing threat. More info	Issue Brief
The Threat of Multidrug-Resistant Infections to Children Issue Brief Mar 1, 2012 Expert testimony, research, and commentary More info	Issue Brief
When Multiple Bugs Strike: The Story of Alice Brennan Issue Brief Mar 1, 2012 A healthy immune system may be all the protection someone needs to overcome a bacterial infection, but once one disease takes hold, it may beget more illnesses. Such is often the case with Clostridium difficile, a potentially deadly bacterium that can flourish in the wake of other infections. Senior citizens, such as Alice Brennan, are particularly vulnerable and serve as a reminder that new and powerful antibiotics are needed as protection from dangerous bacterial threats. More info	Issue Brief
The Superbug Threat Issue Brief Mar 1, 2012 As Drug-resistant bacteria spread, the pipeline for antibiotics is drying up More info	Issue Brief
The Threat of Multidrug-Resistant Infections to the U.S. Military Issue Brief Mar 1, 2012 Expert Testimony, Research, and Commentary Learn More “MDRO multidrug resistant organism infections have become an international health problem during the past several decades and now pose a challenge to the care of our wounded military personnel.” — D. Hospenthal More info	Issue Brief
Patient Story: Jamel Sawyer: A Young Man Fights MRSA Issue Brief Jan 2, 2012 One of the most notorious multidrug-resistant superbugs, MRSA is responsible for an estimated 19,000 deaths and 360,000 hospitalizations each year in this country. Jamel’s story illustrates the twin dangers presented by emerging multidrug-resistant bacterial infections and the waning effectiveness and availability of drugs to treat them. More info	Issue Brief
National Headlines Reporting on the Need for New, Lifesaving Antibiotics Issue Brief Sep 20, 2011 National and international headlines warn that multidrug-resistant superbugs are on the rise and the pipeline of new antibiotics is running dry. More info	Issue Brief
What Leading Experts are Saying about Emerging Drug-Resistant Infections and the Need for New Drugs to Treat Them Issue Brief Sep 20, 2011 Legislators, regulators, scientists and academics agree: we are running out of antibiotics to treat drug-resistant infections—and we need new ones now. Here is what leading voices are saying about how economic, scientific and regulatory factors are impeding the development of new antibiotics, and what we can do about it. More info	Issue Brief

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feature

Drug Development for Limited Populations

The lack of new antibiotics and the rise in drug resistance have rendered some serious and life-threatening infections untreatable, and the health care community is searching for ways to bring innovative new drugs to patients whose treatment options are limited or nonexistent.

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feature

What's Your Antibiotics IQ?

Antibiotics save untold numbers of human lives every day. Modern medicine depends on their ability to treat and prevent infections such as pneumonia and staph. Yet drug-resistant bacteria are spreading and too often antibiotics are taken for granted. Test your knowledge.

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Allan Coukell Senior Director, Drugs and Medical Devices The Pew Charitable Trusts

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Nicole Mahoney Senior Officer, Antibiotics and Innovation The Pew Charitable Trusts

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Antibiotics and Innovation Project